Head of In Vitro & In Vivo iADME - Brussels

Functiegroepen: Clinical Research / Clinical Pharmacokinetics/DMPK


In their continued efforts regarding the discovery and development of groundbreaking medicines and solutions for severe immune system and CNS diseases this organisation is looking for a skilled Head of In Vitro & In Vivo iADME. This international organisation (over 8.000 headcount and active in over 40 counties) would like this professional to work in Brussels, from where he or she will lead teams both in Belgium as in the UK.


In this strategic and scientific role you will be reporting directly to the Head of Global iADME. On a day to day basis, you will find yourself in a collaborative environment where you will be responsible for multiple projects along the full value chain from early discovery to post marketing. Your colleagues will be looking at you when it comes to providing clear scientific and strategic direction, including novel methodologies and platforms using state of the art technologies for the assessment of ADME properties of the current pipeline.

To summarise this exciting global managerial role:

  • You will be a manager for staff both in Belgium and the United Kingdom
  • You will ensure a highly innovative mindset among staff and guide development of new assays in the DMPK/ADME arena
  • While tactically assigning resources (personnel, space and equipment), implementing programs, and driving process improvement to assure financial and budget expectations are met and ensuring quality and timely delivery of the project deliverables
  • In addition you will be responsible for overseeing performance of group personnel; coach younger staff to foster a highly innovative mindset and guide development of new assays, being a role model for scientific excellence as well as promote full career development potential
  • You will contribute to the overall assignments of the leadership team in Global iADME
  • Also you will increase ADME/DMPK visibility (internally and externally) by demonstrating scientific excellence and credibility, representing the organisation in conferences, act as committee member on external scientific boards and organisations and engage in collaborations with academic institutions
  • Continuously you will show ability to champion and develop new scientific or process strategic directions
  • You will interact with and influence key collaborators/stakeholders and leaders across new medicines for an overall understanding of the science needed to progress the organisation’s pipeline
  • You will contribute to clinical plans, regulatory communications and submission documents


As the ideal candidate you can identify with the following profile:


  • You possess a Ph.D. degree in pharmaceutics, pharmacology, drug metabolism or pharmacokinetics, with a minimum of seven years of post-doctoral industrial experience
  • Or you possess a related degree with more than 10 years of industrial experience in the area of DMPK science

When it comes to experience, you have:

  • A documented track record of over 10 years experience in the area of DMPK/ADME and excellent knowledge of ADME/enzymology/drug transporters to couple data to optimisation/selection of NCE, both in discovery and development
  • A proven track record of leading, understanding and hands-on experience for drug metabolism and pharmacokinetics, both in vitro and in vivo studies including human PK prediction, QWBA, DDI prediction and mechanistic understanding to support late stage programs
  • In-depth knowledge of laboratory equipment and instrumentation
  • A solid track record on determination of studies using non-labeled and 14C and 3H-labeled compounds in animals and humans
  • Understanding and experience in PBPK modelling
  • Proven skills for in depth mechanistic understanding of DMPK related issue and of the impact and value of translation to humans
  • Knowledge of the drug development processes in the pharma industry environment
  • Demonstrated managerial and leadership skills

Skills you will be bringing and additional responsibilities:

  • Propose and evaluate new technologies, techniques, study designs or equipment in the DMPK area
  • Ensure the scientific quality and expertise of the global in vitro ADME group
  • Proactive in science and project meetings, and development science meetings, with scientific input, solutions, and alternative approaches picked up from literature
  • Will champion and develop new scientific strategic directions within DMPK area, specifically for enzymatic and transporter interactions and DDI
  • Keep abreast of literature; interact with peers in the DMPK and biotransformation scientific arena
  • Basic skills in bioanalytical scientific area
  • Publish and/or present at conferences on a regular basis
  • Strong communication and collaborative skills together with a driving performance and a decisively way of acting are necessary abilities in a creative and team oriented working environment
  • Good intercultural understanding
  • Strong and mature leadership and influencing skills
  • Fluent spoken and written English


Besides the opportunity to be an integral part of the discovery and development of medicines that will change peoples lives, the organisation:

  • Offers a competitive salary
  • A great secondary package
  • Additional benefits
  • Relocation if needed


If you are interested in this job, or in similar ones, please feel free to contact me directly.

Martin van der Velden
Consultant | Biotechnological and Pharmaceutical Industry


Share on Social Media


To find out what QTC Recruitment can do for you, please contact us. 
Contact us 
Share on Social Media
Hello, how can I help you? I will answer you as soon as possible during working hours.

Press the WhatsApp button again...
Powered by